In a selected group of men with Peyronie’s disease (PD), ESWT appears to be safe, has moderate efficacy and is associated with high patient satisfaction rate in the short term.

Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian men

Eric Chung

The majority of patients have PD history longer than 6 months (mean, 12.8 months; range, 6-28 months). Two thirds of patients have received and failed oral medical therapy. There were improvements in penile curvature (more than 15 degrees in 33% of men), plaque hardness (60% of men) and penile pain (4 out of 6 men) following LiESWT. There was a moderate improvement in IIEF-5 score (>5 points reported in 20% of men). No complication was reported and the majority of patients were satisfied (rated 4 out of 5; 70% of men) and would recommend this therapy to others.

Shown effective in patient age ≥18 years, failed medical therapy, presence of palpable plaque and/or penile pain, and penile curvature.

Excluded patients were complex curvature (more than 1 axis deviation or curvature >90 degrees), hourglass deformity, 2 or more palpable plaques, previous Peyronie’s surgery (including penile prosthesis implant) and significant ED unresponsive to medical therapy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643174/